Research at Peptide ChemistryOur group is mainly interested in syntheses of modified peptides. We have developed a synthesis of peptide antigene carriers on polyethylene glycols. Both, chemical and enzymatical detachment were employed in final cleavage steps [ref]. Succesful, touch of acridine peptide chemistry was acheived. We can moderate 9-aminoacridine affinity for nucleic acids [ref], as well as, select compounds which may prevent interaction of DNA and prion peptide [ref]. We also contribute on several scientific meeting, posters and lectures are available from sites such as 29EPS, ....Recent papersSebestik, J.; Hlavacek, J. and Stibor, I.;Rational design and synthesis of double-stranded DNA-binder libraryBiopolymers (Pept. Sci.)200684400-407[Article]
Sebestik, J.; Stibor, I. and Hlavacek, J.;New Peptide Conjugates with 9-Aminoacridine: Synthesis and Binding to DNAJ. Pept. Sci.200612472-480[Article]
Niederhafner, P.; Safarik, M.; Sebestik, J.; Gut, V.; Malon, P. and Hlavacek, J.;Synthesis of protected peptides from the human IgG1 hinge region on PEG support using disulfide bond synthons and alkaline or enzymatic detachmentTetrahedron Lett.2006471023-1025[Article]
Sebestik, J.; Niederhafner, P.; Safarik, M. and Hlavacek, J.;Electrophoresis of Derivatized Polyethylene Glycols: A Useful Method for Monitoring of Reactions on Soluble Polymeric Carrier.International Journal of Peptide Research and Therapeutics 200511291-296[Article]
Bour, P.; Budesinsky, M.; Spirko, V.; Kapitan, J.; Sebestik, J. and Sychrovsky, V.;A Complete Set of NMR Chemical Shifts and Spin-Spin Coupling Constants for L-Alanyl-L-alanine Zwitterion and Analysis of Its Conformational Behavior.J. Am. Chem. Soc.200512717079-17089[Article]
Sebestik, J.; Hlavacek, J. and Stibor, I.;Molecular recognition of cyclic-nucleotides and current sensors for their detection.Curr. Protein Pept. Sci.20056133-142[Review]
Sebestik, J.; Matejka, P.; Hlavacek, J. and Stibor, I.;Solid-phase synthesis of head and tail bis-acridinylated peptides.Tetrahedron Lett.200445 1203-1205[Article]
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